The APhA Foundation’s Project IMPACT Depression employed enhanced employee outreach, patient education, and systematic follow-up by pharmacists  to improve the outcomes of depressed patients. Partnering employer groups changed the way they paid for health care by aligning incentives for patients and providers. Covered beneficiaries received waived copayments, as they participated in the depression management program that empowered them to live healthier lives. Following consultations with a pharmacist, patients increased their medication adherence and took steps to make lifestyle changes resulted in quantifiable benefits apparent in clinical and economic outcomes.